| 5-羟色胺载体蛋白基因和5-羟色胺2A受体基因对注意缺陷多动障碍患儿智商的交互作用 |
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| 引用本文： | 钱秋谨,王玉凤,李君,杨莉,陈芸,吉宁,刘璐.5-羟色胺载体蛋白基因和5-羟色胺2A受体基因对注意缺陷多动障碍患儿智商的交互作用[J].实用儿科临床杂志,2010(2). |
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| 作者姓名： | 钱秋谨 王玉凤 李君 杨莉 陈芸 吉宁 刘璐 |
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| 作者单位： | 北京大学精神卫生研究所儿童室;卫生部精神卫生学重点实验室; |
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| 基金项目： | 卫生行业科研专项经费项目(200802073); 国家自然科学基金(30770774); “十一五”国家科技支撑计划(2007BAI17B03) |
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| 摘 要： | 目的探讨5-羟色胺(5-HT)系统中5-HT载体蛋白(5-HTT)基因和5-HT2A受体(5-HTR2A)基因对注意缺陷多动障碍(ADHD)患儿智商的交互作用。方法对233例中国汉族ADHD患儿进行韦氏智力测查,并采用限制性片段长度多态性(RFLP)的方法检测5-HTT基因第2内含子(Stin2)17bp的可变数目顺向重复(VNTR)多态性(Stin2.VNTR)和5-HTR2A启动子区-1438A/G多态性。结果5-HTT基因和5-HTR2A基因交互作用对全量表智商(FSIQ)和操作智商(PIQ)有明显的预测作用(F=7.011,P=0.009;F=10.246,P=0.002)。在所有基因型组合中,10R12R-GG基因型可提示最高智商(FSIQ:113.0±4.5,95%CI:104.2～121.8;PIQ:111.2±4.7,95%CI:101.9～120.6),10R12R-GA/AA基因型提示最低智商(FSIQ:91.9±2.9,95%CI:86.3～97.5;PIQ:89.2±3.0,95%CI:83.2～95.2)。5-HTR2A的-1438A/G与患儿的FSIQ、PIQ和言语智商(VIQ)存...
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| 关 键 词： | 注意缺陷多动障碍 基因 智力 5-羟色胺 交互作用 |
Gene-Gene Interaction between Serotonin Transporter Gene and Serotonin 2A Receptor Gene on Intelligence of Children with Attention Deficit Hyperactivity Disorder |
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| QIAN Qiu-jin,WANG Yu-feng,LI Jun,YANG Li,CHEN Yun,JI Ning,LIU Lu.Gene-Gene Interaction between Serotonin Transporter Gene and Serotonin 2A Receptor Gene on Intelligence of Children with Attention Deficit Hyperactivity Disorder[J].Journal of Applied Clinical Pediatrics,2010(2). |
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| Authors: | QIAN Qiu-jin WANG Yu-feng LI Jun YANG Li CHEN Yun JI Ning LIU Lu |
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| Institution: | QIAN Qiu-jin,WANG Yu-feng,LI Jun,YANG Li,CHEN Yun,JI Ning,LIU Lu(Institute of Mental Health,Peking University,Key Laboratory of Mental Health,Ministry of Health,Beijing 100191,China) |
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| Abstract: | Objective To investigate the gene-gene interaction between serotonin transporter (5-HTT) gene and serotonin 2A receptor (5-HTR2A) gene in the role for intelligence of children with attention deficit hyperactivity disorder(ADHD).Methods A total of 233 ADHD children of Chinese Han descent were included,and the complete intelligence quotient(IQ) evaluation were detected,and two polymorphisms of serotonin transporter intron 2 variable number tandem repeat(stin2.VNTR) and -1438A/G polymorphism in the 5-HTR2A gen... |
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| Keywords: | attention deficit hyperactivity disorder gene intelligence serotonin interaction |
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