移居高原老年高血压患者胰岛素敏感性的临床观察

目的：了解在高原环境（海拔2200m-3800m）及饮食条件下，移居高原的60岁以上的高血压患者胰岛素抵抗情况。方法：对32名移居及36名世居60岁以上1级、2级高血压患者行血压、血脂、空腹血糖及空腹胰岛素检验，应用Homa Model稳态模型分析法评估胰岛素抵抗状况。结果：移居高原的60岁以上的高血压患者由于受自然环境及饮食生活方式影响，收缩压及空腹胰岛素水平均较世居者高，出现明显胰岛素抵抗。结论：移居的高血压患者与世居者存在着胰岛素敏感性或β细胞功能的差异。

Clinical Observation of Insulin Sensitivity in Migrated Old Men with Hypertension at High Altitude

Objective: To understand the changes of insulin sensitivity in the old migrants with hypertension under altitude environment and diet. Methods: Blood pressure, level of blood lipid, last blood glucose and insulin were measured in 32 migrants and 36 natives aged 60 years or older, and were evaluated on resistant of insulin by Homa model.Results: The systolic blood pressure and the level of last blood glucose in the migrants were high than that in the natives, and there was a significant insulin resistant effect. Conclusions: There is a difference of insulin sensitivity and ? cell function between old migrants and natives with hypertension at high altitude.