乌灵胶囊作为黛力新的增效剂治疗卒中后抑郁疗效的Meta分析

目的：系统评价乌灵胶囊作为黛力新的增效剂治疗卒中后抑郁（PSD）的疗效和安全性。方法系统检索 PubMed 、Cochrane 图书馆、万方医学网、中国知网、EMbase 和 Web of Science 等数据库中关于乌灵胶囊作为黛力新的增效剂治疗 PSD 疗效的随机对照试验（RCT ）。截止时间设定到2016年2月。两名评价员根据预先设定的标准独立地进行文献筛选和数据提取，Meta 分析使用 RevMan 5.2软件。结果共有11篇 RCT 符合纳入标准。 Meta 分析结果显示，与单用黛力新相比，乌灵胶囊联合黛力新能更好地降低抑郁评分（SM D ＝－1．72，95％ CI ＝－2．08～－1．36，P ＜0．01）和神经功能缺损评分（SM D ＝－1．27，95％ CI ＝－1．80～－0．74，P ＜0．01），总有效率更高（RR ＝1．12，95％ CI ＝1．05～1．19，P ＜0．01），且不良反应更少（RR ＝0．54，95％ CI ＝0．35～0．83，P ＜0．01）。结论乌灵胶囊作为增效剂能显著提高黛力新治疗 PSD 的疗效，且安全性更好。

Meta-analysis of wuling capsule as synergist for deanxit on post stroke depression

Objective To systematically assess the efficacy and safety of wuling capsul as synergist for deanxit on post stroke depression (PSD) .Methods The randomized controlled trial(RCT ) of wuling capsule as synergist for deanxit on PSD were retrieved systematically in PubMed ,Cochrane Li-brary ,Wanfang ,CNKI ,EMbase and Web of Science databases .The deadline was seted by February 2016 . Two reviewers screened the literature and data extraction according to preset criteria independently .RevMan 5 .2 was used to do meta - analysis .Results Totally ,eleven RCTs were included . Meta - analysis showed that ,compared with the single - use deanxit ,wuling capsule with deanxit could better able to reduce depression score (SM D = - 1 .72 ,95% CI = - 2 .08- - 1 .36 ,P < 0 .01) and neuro-logical deficit score (SM D = - 1 .27 ,95% CI = - 1 .80- - 0 .74 ,P < 0 .01) ,to get a higher total efficien-cy (RR = 1 .12 ,95% CI = 1 .05 - 1 .19 ,P < 0 .01) and fewer adverse reactions (RR = 0 .54 ,95% CI =0.35 - 0 .83 ,P < 0 .01) .Conclusions Wuling capulse as a synergist can significantly improve the efficacy of deanxit on treating PSD and better security .