| 慢性捆绑应激对大鼠学习记忆及海马I-B4表达的影响 |
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| 引用本文： | 廖敏,陈世新. 慢性捆绑应激对大鼠学习记忆及海马I-B4表达的影响[J]. 咸宁医学院学报, 2004, 18(1): 22-23 |
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| 作者姓名： | 廖敏 陈世新 |
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| 作者单位： | 咸宁学院医学院组织胚胎学教研室，咸宁学院生物医学工程系 湖北咸宁437100 |
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| 摘 要： | 目的探讨小胶质细胞在应激中的作用。方法把大鼠分为应激组和正常对照组 ,应激组大鼠每天捆绑6h ,持续 2 1d ,然后用Y迷宫测试两组大鼠学习记忆能力 ,应用免疫组织化学方法测定两组大鼠海马小胶质细胞I-B4的表达。结果应激组大鼠学习记忆能力明显受损 (P <0 .0 5 ) ,其海马小胶质细胞I -B4免疫阳性产物较对照组明显增加 (P <0 .0 5 )。结论慢性捆绑致大鼠学习记忆受损可能与海马小胶质细胞I-B4表达增加有关。
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| 关 键 词： | 慢性捆绑应激 大鼠 学习记忆 海马 I-B4 免疫组织化学 测定 |
| 文章编号： | 1008-0635(2004)01-0022-02 |
| 修稿时间： | 2003-10-09 |
Effect of the Chronic Restraint Stress upon Learning and Memory and upon Expression of I-B4 in Hippocampus |
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| LIAO Min,CHEN Shi-xin. Effect of the Chronic Restraint Stress upon Learning and Memory and upon Expression of I-B4 in Hippocampus[J]. Journal of Xianning Medical College, 2004, 18(1): 22-23 |
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| Authors: | LIAO Min CHEN Shi-xin |
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| Affiliation: | LIAO Min1,CHEN Shi-xin2 |
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| Abstract: | Objective To explore the role of microglia in chronic restraint stress. Methods Rats were divided into stress and control groups. The stress rats were restrained for 6 hours every day for 21 days, and then the behavior of rats in two groups was tested respectively by Y-maze and the expression of the I-B4 in hippocampus of those rats in two groups were observed by immunocytochemical method. Results The learning and memory ability of the stress rats was impaired (p<0.05). The immunoreactivities of the I-B4 were increased in hippocmpal of the stress rats (p<0.05).Conclusion The impairment of learning and memory ability of the stress rats might be related to the change of the I-B4 in hippocampal microglia of the rats. |
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| Keywords: | Chronic restraint stress Learning and memory Microglia I-B4 |
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