In Vivo Activation of Mouse Macrophages with β-l,3-D-Glucan-Derivatized Plastic Beads |
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| Authors: | R. SELJELID,J. BØ GWALD,L.-T. RASMUSSEN,O. LARM,J. HOFFMAN,A. BERGE,J. UGELSTAD |
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| Affiliation: | Institute of Medical Biology, University of Tromsø, TromsøNorway;Department of Chemistry and Molecular Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden;and Division of Applied Chemistry, The Foundation of Scientific and Industrial Research at the Norwegian Institute of Technology, Trondheim, Norway |
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| Abstract: | Macrophages obtained from animals treated with beta-1,3-D-glucan-derivatized plastic beads were greatly stimulated, as judged by morphology, esterase release, and cytostatic effect on L-929 tumour cells in vitro. The pretreatment of mice with such beads conferred an apparent absolute local resistance to an otherwise lethal pneumococcal infection but had no effect on the growth of intraperitoneal AA ascites sarcoma. Moreover, peritoneal cells from animals pretreated with glucan beads did not protect the animals in a Winn assay. |
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