| Mutations in the D-loop region of mitochondrial DNA in g astric cancer |
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| 作者姓名： | Yibing Zhao Hongyu Yang Guoyu Chen |
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| 作者单位： | DepartmentofGastrointestinalSurgery,theFirstAffiliatedHospitalofNanjingMedicalUniversity,Nanjing210029,China |
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| 摘 要： | Objective: To investigate the mutations in the D-loop region of mitochondrial DNA (mtDNA) in gastric cancer.Methods: The mtDNA of D-loop region was amplified by PCR and ,sequenced in 20 samples from gastric cancer tissue and adjacent normal membrane. Results: There were 7/20(35% ) mutations in the mtDNA of D-loop region in gastric cancer patients. There were four microsatellite instabilities among the 18 mutations. Nine new polymorphisms were identified in 20 patients. Conclusion: The mtDNA of D-loop region might be highly polymorphoric and the mutation rate is high in patients with gastric cancer.
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| 关 键 词： | D-loop 线粒体DNA 胃肿瘤 基因突变 |
Mutations in the D-loop region of mitochondrial DNA in gastric cancer |
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| Yibing Zhao,Hongyu Yang,Guoyu Chen.Mutations in the D-loop region of mitochondrial DNA in g astric cancer[J].Acta Universitatis Medicinalis Nanjing,2005,19(2):95-98. |
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| Authors: | Yibing Zhao Hongyu Yang Guoyu Chen |
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| Institution: | Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | Objective: To investigate the mutati ons in the D-loop region of mitochondrial DNA (mtDNA) in gastric cancer. Methods: The mtDNA of D-loop region was amplified by PCR and sequence d in 20 samples from gastric cancer tissue and adjacent normal membrane. Results: There were 7/20(35%) mutations in the mtDNA of D-loop regio n in gastric cancer patients. There were four microsatellite instabilities among the 18 mutations. Nine new polymorphisms were identified in 20 patients. Conclusion: The mtDNA of D-loop region might be highly polymorphoric and the mutation rate is high in patients with gastric cancer. |
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| Keywords: | mitochondrial DNA D-loop mutation |
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