恶性肿瘤维医证型与血栓前状态分子标志物的关系研究

目的 探讨恶性肿瘤患者维医证型与血栓前状态分子标志物的关系。

Study on the Correlation between Prethrombotic Biomarkers and Traditional Uyghur Medicinal Syndromes of Malignant Tumor

Objective To study the correlation between prethrombotic biomarkers and traditional Uyghur medicinal syndromes of malignant tumor.Methods One hundred and fifty-nine malignant tumor inpatients were randomly selected and typed according to traditional Urgur medicine theories.The expressions of peripheral platelet membrane glucoprotein（CD41 and CD62p）,levels of serum endothelin（ET-1）,plasma tissue plasminogen activator（t-PA）,plasminogen activator inhibitor（PAI）,plasma fibrinogen（FIB）,prothrombin time（PT）,and thrombin time（TT）,and activated partial thromboplastin time（APTT） were detected by flow cytometry,radioimmunoassay,and enzyme-linked immunosorbnent assay（ELISA） respectively.Results The patients were typed as 68 of abnormal Savda syndrome,34 of abnormal Khan syndrome,31 of the abnormal Sepra syndrome,and 26 of the abnormal Belghem syndrome.Compared with the control group,the levels of CD62p,PAI,and ET-1 increased,levels of FIB and t-PA decreased,PT prolongated and APTT shortened in the abnormal Savda group and the non-abnormal Savda group（including abnormal Khan,abnormal Sepra,and abnormal Belghem types）（all P0.05）.No significant difference of CD41or TT was shown in inter-group comparison（P0.05）.Compared with abnormal Khan and Belghem groups,the ET-1 level increased in the abnormal Savda group（P0.05）.Compared with the abnormal Sepra group,the CD62p positive percentage increased in abnormal Savda group（P0.05）.No significant difference in CD41 positive percentage,t-PA or PAI-1 contents,PT,TT,or APTT was shown in patients of different traditional Uyghur medicine syndrome groups（P0.05）.Conclusions Prethrombotic changes existed in malignant tumor patients of different Uyghur abnormal syndrome types,manifested as injuries of vessel epithelial cells,platelet activation,increased blood viscosity,lowered fibronolytic function.The prethrombotic changes were more obviously seen in the abnormal Savda group.