| 壳聚糖对豚鼠单一心室肌细胞延迟外向钾电流的作用 |
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| 引用本文： | 李金鸣,张沈丽.壳聚糖对豚鼠单一心室肌细胞延迟外向钾电流的作用[J].中国海洋药物,1998,17(4):4-7. |
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| 作者姓名： | 李金鸣 张沈丽 |
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| 作者单位： | 中国医科大学药理教研室，中国医科大学药理教研室，中国医科大学药理教研室，中国医科大学药理教研室，中国医科大学药理教研室 沈阳 110001，沈阳 110001，沈阳 110001，沈阳 110001，沈阳 110001 |
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| 摘 要： | 研究壳聚糖对豚鼠单一心室肌细胞延迟外向钾电流（Ｉｋ）的作用，从离子通道角度初步春作用机理。应用膜片钳全细胞记录方式，设保持电位为－４０ｍＶ，指令电位为－６０￣＋７０ｍＶ，步阶脉冲１０ｍＶ，刺激频率１Ｈｚ，波宽３００ｍｓ，刺激间隔６ｓ的方波钳制方案。结果表明壳聚糖能抑制Ｉｋ，并具有浓度依赖关系，能抑制豚鼠单一心室肌细胞延迟外向Ｋ＾＋电流。
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| 关 键 词： | 壳聚糖 单一心室肌细胞 抗心律失常药物 Ik |
EFFECT OF CHITOSAN ON DELAYED OUTWARD POTASSIUM CURRENT IN SINGLE VENTRICULAR MYOCYTES OF GUINEA PIG |
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| Li Jinming,Zhang Shenli,Xiao Qinghuan,Wang Yuping,Zhang Keyi,et al.EFFECT OF CHITOSAN ON DELAYED OUTWARD POTASSIUM CURRENT IN SINGLE VENTRICULAR MYOCYTES OF GUINEA PIG[J].Chinese Journal of Marine Drugs,1998,17(4):4-7. |
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| Authors: | Li Jinming Zhang Shenli Xiao Qinghuan Wang Yuping Zhang Keyi |
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| Abstract: | To study the effect of chitosan on delayed outward potassium current(IK) in single ventricular myocytes of guinea pig and investigate its antiarrhythmic mechanism from ion channel view. Patch clamp technique with whole-cell configuration. Holding potential was -40mV,commanding potential was -60- + 70mV ,step pulse +10mV,stimulating frequency 1 Hz,duration 300 ms and stimulating interval 6s. The result showed that Chitosan inhibited IK in a dose -dependent manner. Conclusion :Chitosan can inhibite IK in single ventricular myocytes of guinea pig. |
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| Keywords: | Chitosan Patch clamp technique IK single ventricular myocyte |
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