Neonatal myasthenia gravis: Clinical and immunological study of seven mothers and their newborn infants |
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| Authors: | E. Bartoccioni A. Evoli C. Casali C. Scoppetta P. Tonali C. Provenzano |
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| Affiliation: | 1. Institute of General Pathology, Catholic University, Largo F. Vito 1, 00168 Rome, Italy;2. Institute of Neurology, Catholic University, Largo F. Vito 1, 00168 Rome, Italy;1. Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania;2. Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;3. Comprehensive Vascular Anomalies Program, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;4. Section of Interventional Radiology, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania;1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China;2. College of Life Science, Inner Mongolia Agricultural University, Hohhot, 010018, China;3. Inner Mongolia Key Laboratory of Biomanufacturing, Hohhot, China;1. Division of Neonatal Medicine, Department of Pediatrics, University of Rochester, Rochester, NY;2. Division of Neonatal and Developmental Medicine, Department of Pediatrics Lucile Packard Children׳s Hospital at Stanford University, Stanford University, Palo Alto, CA;3. Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket St, Pittsburgh, PA 15213;1. Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut School of Medicine, Farmington, Connecticut;2. Department of Surgery, University of Connecticut School of Medicine, Farmington, Connecticut |
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| Abstract: | We studied 7 mothers with myasthenia gravis (MG) and their infants. We confirmed that the development of neonatal MG was not related to the serum titer of maternal anti-acetylcholine receptor antibody (anti-AChR ab). To investigate the possibility that specific immunization of the newborn infant had occurred, serial serum determinations of total and 'specific' anti-AChR IgG and IgM were performed. We found that: the decay in total IgG was within the normal range in all the babies; there was a shorter half-life of 'specific' IgG, compared to total IgG, in 3 of the cases, 2 of which did have neonatal MG; no difference was found between the decay of anti-AChR ab in the babies who had neonatal MG and those who did not; there was no anti-AChR IgM-associated activity. Our data suggest that neonatal MG is due to maternal anti-AChR abs and that affected infants do not produce specific antibodies. |
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| Keywords: | Acetylcholine receptor - Anti-acetylcholine receptor antibody - Myasthenia gravis |
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