| 吡咯-2-硫代甲酰胺的简易合成方法 |
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| 引用本文： | 蓝晓步,王尔华.吡咯-2-硫代甲酰胺的简易合成方法[J].药学进展,2004,28(1):42-43. |
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| 作者姓名： | 蓝晓步 王尔华 |
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| 作者单位： | 中国药科大学医药化工研究所,江苏,南京,210009 |
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| 摘 要： | 目的：改进制备吡咯-2-硫代甲酰胺的方法。方法：以硫氰酸钾、氯甲酸乙酯和吡咯为原料经亲电取代，水解等反应合成制备目标产物。结果：该方法工艺简单，后处理方便，且产率高，反应条件温和。结论：该合成路线易于工业化生产。
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| 关 键 词： | 吡咯-2-硫代甲酰胺 异硫氰基甲酸乙酯 合成 工业化生产 |
| 文章编号： | 1001-5094(2004)01-0042-02 |
| 修稿时间： | 2003年11月17 |
Facile Synthetic Method for Pyrrole-2-thiocarboxamide |
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| LAN Xiao-bu,WANG Er-hua.Facile Synthetic Method for Pyrrole-2-thiocarboxamide[J].Progress in Pharmaceutical Sciences,2004,28(1):42-43. |
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| Authors: | LAN Xiao-bu WANG Er-hua |
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| Abstract: | Objective:To improve the preparation of Pyrrole-2-thiocarboxamide. Methods:The pyrrole-2-Thio-carboxamide is prepared from elctrophilic substition, and hydrolyzed by reacting with potassium thiocyanate, ethyl chloroformate and pyrrole by using suitable method of aftertreament. Results:This method is simple and convenient. The yield is better than that reported before, and the reacting condition is moderate. Conclusion:This synthesis route is practical and easy to popularize in industry. |
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| Keywords: | Ethoxycarbonyl Isothiocyanate Pyrrole Pyrrole-2-thiocarboxamide Synthesis |
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