Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism |
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Authors: | Bynoe Margaret S Viret Christophe |
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Affiliation: | College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA. msb76@cornell.edu |
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Abstract: | Foxp3(+)CD4(+) T cells represent a population of naturally arising suppressor T cells that are crucial for the control of autoimmune responses. The suppressive activity of this T cell subset relies on multiple mechanisms that include secretion of anti-inflammatory factors such as TGF-beta or IL-10. Novel studies now establish that, through the generation of the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to the regulatory activity of Foxp3(+)CD4(+) T cells. |
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