| 特发性血小板减少性紫癜T淋巴细胞功能异常的研究 |
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| 引用本文： | 刘晓莉,张茂宏,彭军,张锑,梁辉. 特发性血小板减少性紫癜T淋巴细胞功能异常的研究[J]. 上海交通大学学报(医学版), 2004, 24(9): 742-744 |
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| 作者姓名： | 刘晓莉 张茂宏 彭军 张锑 梁辉 |
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| 作者单位： | [1]上海第二医科大学新华医院血液科,上海200092 [2]山东大学齐鲁医院血液科,上海200092 |
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| 摘 要： | 目的 研究特发性血小板减少性紫癜(ITP)患者T淋巴细胞功能变化，探讨T细胞在ITP发病机制中的作用。方法 采用FACS分析CD3^ T细胞表面CD28的表达；ELISA法检测血清IL-2水平。结果 ITP患者CD3^ T细胞表面CD28的表达率和血清IL-2水平均显著高于正常对照组，两者呈正相关。结论 ITP患者T淋巴细胞异常活化，细胞因子分泌失调，破坏自身免疫耐受。
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| 关 键 词： | ITP 特发性血小板减少性紫癜 患者 T淋巴细胞功能 CD3^＋T细胞 IL-2 CD28 水平 结论 目的 |
| 文章编号： | 0258-5898(2004)09-0742-03 |
| 修稿时间： | 2003-08-25 |
Study on the function of T lymphocytes in idiopathic thrombocytopenic purpura |
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| LIU Xiao-li,ZHANG Mao-hong,PENG Jun,ZHANG Ti,LIANG Hui. Study on the function of T lymphocytes in idiopathic thrombocytopenic purpura[J]. Journal of Shanghai Jiaotong University:Medical Science, 2004, 24(9): 742-744 |
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| Authors: | LIU Xiao-li ZHANG Mao-hong PENG Jun ZHANG Ti LIANG Hui |
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| Abstract: | Objective Study on the function of T lymphocytes in idiopathic thrombocytopenic purpura(ITP) in order to investigate the role of T lymphocytes in the pathogenesis in ITP. Methods The expression rate of CD28 was tested by FACS. Sera were bioassayed for IL-2 content using ELISA. Results Both the expression of CD28 on CD3+ cells and the serum level of IL-2 were much higher in ITP patients than in controls. They were in positive correlation. Conclusion Abnormal activation of T cells and disregulated cytokine secretion in ITP lead to the breakdown of immune tolerance. |
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| Keywords: | idiopathic thrombocytopenic purpura T lymphocyte CD_(28) IL-2 |
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