| 光度法测定咖啡因、烟酰胺、水杨酸等配体与萘普生在水溶液中的形成常数 |
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| 引用本文： | 施庆和,王集金,刘旭东,张建华. 光度法测定咖啡因、烟酰胺、水杨酸等配体与萘普生在水溶液中的形成常数[J]. 药学学报, 1989, 24(4): 280-284 |
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| 作者姓名： | 施庆和 王集金 刘旭东 张建华 |
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| 作者单位： | 内蒙古医学院药学系，内蒙古医学院药学系，内蒙古医学院药学系，内蒙古医学院药学系 呼和浩特 010059，呼和浩特 010059，呼和浩特 010059，呼和浩特 010059 |
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| 摘 要： | 本文通过萘普生和咖啡因、烟酰胺、水杨酸等配体紫外光谱的测定,Job连续递变法实验,确定了它们之间的相互作用。其形成物的比值均为1:1。并用紫外分光光度法测定了形成常数,进而推算了热力学函数,推测了其可能的形成机理。
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| 关 键 词： | 咖啡因 烟酰胺 水杨酸 萘普生 形成常数 |
| 收稿时间： | 1988-01-29 |
SPECTROPHOTOMETRIC DETERMINATION OF COMPLEX FORMATION CONSTANTS OF NAPROXEN WITH CAFFEINE, NICOTINAMIDE AND SALICYLIC ACID IN AQUEOUS SOLUTION |
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| QH Shi,JJ Wang,XD Liu and JH Zhang. SPECTROPHOTOMETRIC DETERMINATION OF COMPLEX FORMATION CONSTANTS OF NAPROXEN WITH CAFFEINE, NICOTINAMIDE AND SALICYLIC ACID IN AQUEOUS SOLUTION[J]. Acta pharmaceutica Sinica, 1989, 24(4): 280-284 |
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| Authors: | QH Shi JJ Wang XD Liu JH Zhang |
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| Abstract: | The interaction between water insoluble drug naproxen with caffeine, nicotinamide and salicylic acid in aqueous solutions were determined by spectrophotometry. Naproxen was found to form 1:1 molecular complex with these substances. The complex formation constants were determined by spectrophotometry at room temperature. The thermodynamic functions associated with complexation of naproxen-drugs were also evaluated. It may be concluded that the complex formation may be attributed to hydrogen bonding since enthalpy changes were shown to be a few KJ.mol-1. |
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| Keywords: | Caffeine Nicotinamide Salicylic acid Naproxen Formation constant |
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