Effects of isosorbide dinitrate on the pattern of arterial blood flow in healthy human subjects |
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Authors: | C G Caro P J Fish D E Goss J Halls M J Lever K H Parker A S Clear |
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Affiliation: | Physiological Flow Studies Unit, Imperial College, London. |
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Abstract: | 1. Blood velocity measurements have been made in the superficial femoral artery, 10 cm downstream of the common femoral artery bifurcation, in healthy human subjects, using a multi-channel Doppler ultrasound device. 2. In a randomized double-blind protocol, the effects of isosorbide dinitrate were examined during a 2 h period. 3. The changes induced by isosorbide dinitrate include: (i) an increase in the width of the artery and a reduction in brachial arterial blood pressure, implying relaxation of arterial smooth muscle; (ii) an increase in reverse flow and a decrease in time-averaged mean velocity associated with a relatively small decrease of the velocity excursion during the cardiac cycle, implying an increase in flow pulsatility; and (iii) an alteration of the flow pattern both in the core and near the vessel walls. |
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