急性冠脉综合征患者D31阳性CD42阴性内皮微粒的检测及其临床意义

目的 研究血浆CD31阳性CD42阴性的细胞微粒（CD-31 CD-42EMP）能否作为急性冠状动脉综合征患者危险程度的标志物.方法 收集62例急性冠脉综合征和62例稳定型冠心病患者及62例健康志愿者的血浆,用流式细胞术测定CD＋31 CD-42EMP水平,同时测定血浆超敏C-反应蛋白的水平.结果 与健康志愿者组比较,稳定型冠心病组患者CD＋31 CD-42EMP水平和超敏C-反应蛋白的水平明显升高,差异有显著性;与稳定型冠心病组患者及健康志愿者组比较,急性冠脉综合征组患者的CD＋31 CD-42EMP水平和超敏C-反应蛋白的水平明显升高,差异具有显著性.结论 CD＋31 CD-42EMP水平能作为急性冠脉综合征危险程度的标志物,且与超敏C-反应蛋白的水平有明显相关性.

Measurement and clinic significance of CD3+31 CD4-42 endothelial microparticles with acute coronary syndromes

Abstract] Objective To investigate whether the levels of plasma CD3＋31 CD4-42 endothelial microparticles（CD3＋31 CD4-42 EMP） is one of the makers as acute coronary syndromes （ACS）. Methods Plasma CD3＋31 CD4-42EMP was measured by flow cytometry and hCRP by radioimmunography in 62 patients with ACS, 62 patients with stable coronary heart disease and 62 healthy volunteers. Results Plasma levels of CD3＋31 CD4-42 EMP and hCRP in patients with stable coronary heart disease were significantly elevated, compared to control groups ; Plasma levels of CD3＋31 CD4-42 EMP and hCRP in patients with ACS were significantly elevated compared to other two groups. Conclusion Our data suggested that plasma CD3＋31 CD4-42 EMP levels might be used as a surrogate marker in patients with ACS. Its level was consistent with hCRP.