Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects |
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| Authors: | Mathiesen Sofie Justesen Ulrik Stenz Von Lüttichau Hans-Rudolf Hansen Ann-Brit Eg |
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| Affiliation: | Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen. sofiemath@stud.ku.dk |
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| Abstract: | We present a case with important pharmacogenetic and pharmacokinetic aspects of antiretroviral therapy in a patient with high efavirenz concentrations, severe CNS side-effects and low lopinavir concentrations. Despite therapeutic drug monitoring and subsequent efavirenz dosage reductions, side-effects did not resolve completely and lopinavir concentrations remained relatively low. |
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