Cross-jurisdictional transmission of Mycobacterium tuberculosis in Maryland and Washington,D C, 1996-2000, linked to the homeless |
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Authors: | Lathan Monica Mukasa Leonard Ntaate Hooper Nancy Golub Jonathan Baruch Nancy Mulcahy Donna Benjamin William Cronin Wendy A |
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Affiliation: | Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 21201, USA. |
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Abstract: | From 1996 to 2000, 23 Maryland and Washington, D.C., tuberculosis cases were identified in one six-band DNA cluster. Cases were clustered on the basis of their Mycobacterium tuberculosis isolates. Medical record reviews and interviews were conducted to identify epidemiologic linkages. Eighteen (78%) of the 23 case-patients with identical restriction fragment length polymorphism patterns were linked to another member; half the patients were associated with a Washington, D.C., homeless shelter. Molecular epidemiology defined the extent of this large, cross-jurisdictional outbreak. |
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