抗纤方中药制剂防治肺辐射损伤的临床研究

 目的 探讨抗纤方中药制剂对胸部肿瘤放疗所致肺辐射损伤的预防作用。方法 148例胸部肿瘤患者随机分为实验组70例，对照组78例；均接受胸部肿瘤常规放疗；实验组病例在放疗同时应用抗纤方中药制剂治疗至放疗结束；对照组患者则接受安慰剂治疗。结果 两组放疗后放射性肺炎及放射性肺纤维化的发生率分别为38.4 %，12.8 %和29.4 %，8.5 %，两组比较差异有统计学意义（P＜0.05）。结论 抗纤方中药制剂能够降低胸部肿瘤放疗所致放射性肺炎及肺纤维化的发生率，对肺辐射损伤有明显的预防作用。

Goblet cell carcinoid of the appendix: a clinicopathological analysis of 3 cases

Objective To investigate the histogenesis,clinicopathological features and biological behavior of goblet cell carcinoid (GCC) of the appendix. Methods 3 cases of GCC of the appendix were studied by light microscopy and immunohistochemistry. Results 3 cases all occured in men. Microscopically: the tumor was composed of goblet cells containing mucin-filled with basal round to crescentic nuclei without atypia.These tumor cells were arranged in single forms,nests or acinus with no central lumen. 1 case was composed of simple goblet cells and typical carcinoid cells were seen in other 2 cases arranged in trabeculae and tubule.There was transition between goblet cells with tubelar and crypt epithelium.Immunohistochemical staining revealed that goblet cells were positively reacted with CgA, Syn, CEA, CK and p53 in 1 case. Conclusions Goblet cell carcinoid of the appendix arise from a pluripotent cell with divergent neuroendocrine and mucinous differentiation .It is a subtype of carcinoids of the appendix.The diagnosis mainly bases on its morphologic changes and immunohistochemical findings. The unpredictable behavior of this tumor is probably related to its component and the degree of infiltration.