| 5-甲酰四氢叶酸钙的合成和纯化 |
| |
| 引用本文： | 王彪,张志丽,郭莹,吴晓华,刘俊义.5-甲酰四氢叶酸钙的合成和纯化[J].北京大学学报(医学版),2006,38(4):436-437. |
| |
| 作者姓名： | 王彪 张志丽 郭莹 吴晓华 刘俊义 |
| |
| 作者单位： | (北京大学药学院化学生物学系,天然药物及仿生药物国家重点实验室,北京 100083) |
| |
| 基金项目： | 面向21世纪教育振兴行动计划(985计划) |
| |
| 摘 要： | 目的:建立了一个方便、适用的5-甲酰四氢叶酸钙的制备和纯化方法.方法: 以叶酸为起始物,经NaHSO3还原、甲酸乙酯N5- 甲酰化,NaOH水解与CaCl2在碱性下反应合成5-甲酰四氢叶酸钙. 结果:5-甲酰四氢叶酸钙总产率为54%～59%,比文献值提高了14%～17%.其结构经紫外光谱,核磁共振氢谱及元素分析确证.结论:本方法原料易得、操作简便、产率高,适合工业或大量制备5-甲酰四氢叶酸钙.
|
| 关 键 词： | 醛氢叶酸/化学合成 四氢叶酸盐类 |
| 文章编号： | 1671-167X(2006)04-0436-02 |
| 修稿时间： | 2006年1月5日 |
Study on synthesis and purification of calcium 5-formyltetrahydrofolate |
| |
| WANG Biao,ZHANG Zhi-li,GUO Ying,WU Xiao-hua,LIU Jun-yi.Study on synthesis and purification of calcium 5-formyltetrahydrofolate[J].Journal of Peking University:Health Sciences,2006,38(4):436-437. |
| |
| Authors: | WANG Biao ZHANG Zhi-li GUO Ying WU Xiao-hua LIU Jun-yi |
| |
| Institution: | Department of Chemical Biology, School of Pharmaceutical Science, State Key laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China. |
| |
| Abstract: | Objective: To establish a new approach to synthesis and purification of calcium 5-formytetrahydrofolate Methods: Target compound was synthesized by the use of folic acid as starting material via reduction,formylation,hydrolysis and salt formation Results: The structure of calcium 5-formytetrahydrofolate was confirmed by UV,1H-NMR and elemental analysis and the overall yield was 54%-59%,14%-17% higher than the reported yield.Conclusion: A convenient synthetic route was developed and it would be suitable for industrial production. |
| |
| Keywords: | Leucovorin/chemical synthesis Tetrahydrofolates |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《北京大学学报(医学版)》浏览原始摘要信息 |
| 点击此处可从《北京大学学报(医学版)》下载免费的PDF全文 |
