蛋白质组学技术在胰腺癌诊断中的价值

胰腺癌是一种恶性程度极高的消化道肿瘤,早期诊断较为困难,中晚期胰腺癌手术切除率低,且术后复发转移率高,预后很差.要想改善胰腺癌的预后,必需提高其早期诊断的准确性并有效预测术后复发、转移.近年来,蛋白质组学的发展为胰腺癌及其复发转移的早期诊断带来了希望.利用蛋白质组学技术对胰腺癌的差异蛋白质筛选、分离与鉴定,有利于早期发现胰腺癌的蛋白质(组)变化,建立胰腺癌早期诊断和胰腺癌术后复发、转移的标志物.

Value of proteomics technology in diagnosis of pancreatic cancer

Pancreatic cancer is a highly malignant tumor of digestive tract which early diagnose is very difficult and has low rate of surgical resection of advanced pancreatic cancer. However, the rate of postoperative recurrence and metastas is high. Its prognosis is poor. To improve the prognosis of pancreatic cancer , it is necessary to improve its early diagnosis and effective prediction of postoperative recurrence and metastasis. In recent years, with the development of proteomics, the early diagnosis of pancreatic cancer and its early diagnosis of recurrence and metastasis was possible. Wsing proteomics technology for protein differences screening, isolation and identification is conductive to early detection of pancreatic proteome changes and establishment of the markers for early diagnosis, and recurrence and metastasis of pancreatic cancer.