| 抗癌药物敏感试验（MTT法）在视网膜母细胞瘤化疗中的初步应用 |
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| 引用本文： | 王奭传,郑延川,易虹.抗癌药物敏感试验（MTT法）在视网膜母细胞瘤化疗中的初步应用[J].中华眼底病杂志,1993,9(4):207-209. |
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| 作者姓名： | 王奭传 郑延川 易虹 |
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| 作者单位： | 630014 重庆市第三人民医院眼科 |
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| 摘 要： | 介绍MTT（Tetrazolium dye,四甲基偶氮啖蓝；3-4，5Dimethylthiazol-2,5 diphenyl tetrazolium bromide）抗癌药物敏感试验指导肿瘤患者的术后化疗，并报道用于3例视网膜母细胞瘤（RB）的结果。以肿瘤细胞存活率＜30%为对药物敏感的指标，结果显示同一种抗癌药物对不同的RB患者敏感性不同；抗癌药物单剂使用的效果不如联合使用；单剂作用以卡帕、顺氨氯铂、丝裂霉素C、鬼臼乙叉甙对RB细胞抑制作用较佳，联合使用以卡帕或顺氨氯铂联合长春新碱较佳，但长春新碱单剂使用并不敏感。
（中华眼底病杂志，1993，9：207-209）
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| 收稿时间： | 1993-07-28 |
| 修稿时间： | 1993-10-05 |
MTT ASSAY AS A CHEMOSENTIVITY TEST FOR RETINOBLASTOMA |
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| Wang Shishuang,Zheng Yanchuan,Yihong.MTT ASSAY AS A CHEMOSENTIVITY TEST FOR RETINOBLASTOMA[J].Chinese Journal of Ocular Fundus Diseases,1993,9(4):207-209. |
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| Authors: | Wang Shishuang Zheng Yanchuan Yihong |
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| Institution: | Dept of Ophthalmology,The Third Hospital of Chongqing,630014 |
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| Abstract: | MTT assay was presented in this paper and used in 3 cases of retinoblastoma afert enucleation to evaluate the clinical effect of different chemotherapeutic agents.The results showed that the sensitivity of anticancer agents were various in different cases of retinoblastoma.The combining treatment of tow anticacer agents together was seemingly preferable to a single use.When a single drug was chosen,it was advisable to use carboplatin,cisplatin,mitomycin C or etopside.If a combination of 2 anticancer drugs were applied,vincristin with carboplatin or cisplatin will give a better effect than others,but vincristin is not sensitive when applied alone.（Chin J Ocul Fundus Dis,1993,9:207-209） |
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