Lymphocyte subsets in the peripheral blood of patients with multiple myeloma and benign monoclonal gammopathy |
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Authors: | Herrmann F. Lochner A. Jauer B. Sieber G. Rühl H. |
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Affiliation: | (1) Abteilung für Hämatologie und Onkologie (Prof. Dr. H. Brücher), Medizinische Klinik und Poliklinik, Klinikum Steglitz, Freie Universität Berlin, Germany |
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Abstract: | Summary A panel of monoclonal antibodies that identify various antigens present on T and B cells was used to characterize circulating blood lymphocyte subsets in multiple myeloma [(MM) - 13 patients] and benign monoclonal gammopathy [(BMG) - 5 patients]. In MM and BMG an increase in B cell proportions (BA 1 positive cells) was observed, whereas T cells (Lyt 3 positive cells) were reduced compared to normal controls. However, with respect to the T cell subset distribution, a marked diversity between MM and BMG was noted. This may help to differentiate BMG from MM. In MM a relative decrease in inducer/helper T cells (OKT 4 positive cells) and increase in suppressor/cytotoxic T cells (OKT 8 positive cells) as well as in NK/K T cells (Leu 7 positive cells) was observed. On the other hand, in BMG the relative T cell subset distribution was comparable to those seen in normal subjects.Supported in parts by the Deutsche Forschungsgemeinschaft (Ru 215/2) |
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Keywords: | Multiple myeloma Benign monoclonal gammopathy Lymphocyte subsets Monoclonal antibodies |
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