Incorporation of magnesium ions into photo‐crosslinked alginate hydrogel enhanced cell adhesion ability |
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Authors: | Miao Yin Fei Xu Huifen Ding Fei Tan Fangfang Song Jiawei Wang |
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Affiliation: | 1. Hubei–MOST KLOS and KLOBM, School and Hospital of Stomatology, Wuhan University, People's Republic of China;2. Department of Stomatology, Zhongnan Hospital, Wuhan University, People's Republic of China |
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Abstract: | Photo‐crosslinked alginate hydrogel attracts wide interest in tissue engineering because of its excellent controllability and stability. However, its highly hydrophilic property makes cell adhesion difficult. Plenty of studies have confirmed that magnesium ions (Mg2+) can efficiently improve the attachment of osteoblasts. In this study, for the first time, we fabricated a durable, crosslinked, alginate hydrogel with a dual‐crosslinking network. Photo‐crosslinked alginate hydrogel was chosen as the basic backbone, and various amounts of Mg2+ were incorporated into the hydrogel through ionic crosslinking. The results showed that the physicochemical properties of the hydrogels, including surface structure, composition, swelling ratio, ion release and elastic modulus, could be well tuned by controlling the amount of Mg2+ incorporated. In addition, a certain amount of Mg2+ significantly improved the attachment and spread of osteoblasts on the hydrogels. These characteristics make Mg2+‐incorporated photo‐crosslinked alginate hydrogel a promising scaffold for bone tissue engineering. Copyright © 2015 John Wiley & Sons, Ltd. |
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Keywords: | tissue engineering alginate hydrogel magnesium photo‐crosslink adhesion |
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