血清葡萄糖-6-磷酸异构酶在类风湿关节炎诊断中的价值

目的探讨血清葡萄糖-6-磷酸异构酶（GPI）在类风湿关节炎（RA）诊断中的临床价值。方法采用ELISA法检测GPI和抗环瓜氨酸肽抗体（抗CCP）；间接免疫荧光法检测抗角蛋白抗体（AKA）；速率免疫散射比浊法检测类风湿因子（RF）。共检测65例类风湿关节炎（RA组）、85例其他风湿病患者（非RA组）和60例健康正常成人；（正常对照组）。结果4项血清学指标比较，GPI和抗CCP在诊断RA中有着较高的灵敏度和特异性；RF的灵敏度虽然最高，但特异性却最差。结论GPI对RA早期诊断有着重要的意义，且与抗CCP、AKA、RF无明确的相关性．GPI与RF联合检测更有利于RA的早期诊断。

Value of serum glucose-6-phosphate isomerase in diagnosis of rheuma- toid arthritis

Objective To investigate the clinical value of serum glucose-6-phosphate isomerase （GPI） in the diagno- sis of patients with rheumatoid arthritis （RA）. Methods The GP1 and anti-cyclic citrullinated peptide antibody （anti- CCP） were detected using the ELISA;the anti-keratin antibody （AKA） was detected using the indirect immunofluo- reseence assay;the rheumatoid factor（RF） was detected using the rate immune scattering turbidimetric method. A total of 65 patients with rheumatoid arthritis （RA group）,85 patients with other arthritis （non-RA group） and 60 healthy adults were detected. Results Comparing the 4 serologic indicators, GPI and anti-CCP showed higher sensitivity and specificity in the diagnosis of RA; Though RF had the highest sensitivity, it had the lowest specificity. Conclusion GPI has important significance in the early diagnosis of RA and it does not have clear correlation to anti-CCP, AKA and RF. GPI combined with RF is more beneficial to the early diagnosis of RA.