| 食管小细胞癌与小细胞肺癌凋亡生物学特性的研究 |
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| 引用本文： | 王艳,宋英,许林平,马杰,买玲. 食管小细胞癌与小细胞肺癌凋亡生物学特性的研究[J]. 中国肿瘤, 2008, 17(12): 1067-1069 |
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| 作者姓名： | 王艳 宋英 许林平 马杰 买玲 |
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| 作者单位： | 1. 河南省肿瘤医院,河南,郑州,450003
2. 河南省人民医院,河南,郑州,450003 |
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| 摘 要： | [目的]探讨原发性食管小细胞癌(primary esophageal small cell carcinoma,PESC)和小细胞肺癌(small cell lung carcinoma,SCLC)凋亡生物学特性。[方法]采用免疫组织化学SP法检测survivin,caspase-3,bcl-2,mtp53在PESC和SCLC中的表达。[结果]PESC和SCLC中survivin,caspase-3,bcl-2,mtp534种蛋白的阳性分布无统计学差异(P>0.05)。在PESC和SCLC survivin阴性组中,caspase-3阳性表达率分别为72.41%和62.07%,均明显高于survivin阳性组(30.00%和25.00%,P<0.05)。在这两种小细胞癌中,survivin与caspase-3表达呈负相关;bcl-2与mtp53的表达呈正相关;bcl-2与caspase-3或survivin之间无相关性。[结论]食管小细胞癌和小细胞肺癌的抗凋亡通路存在诸多相同之处,survivin,bcl-2和mtp53均参与了两种小细胞癌的发生发展。
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| 关 键 词： | 食管肿瘤 小细胞癌 小细胞肺癌 细胞凋亡 survivin bcl-2 caspase-3 p53 |
A Study of Apoptosis Biological Characteristics on Primary Esophageal Small Cell Carcinoma and Small Cell Lung Cancer |
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| WANG Yan,SONG Ying,XU Lin-Ping,et al. A Study of Apoptosis Biological Characteristics on Primary Esophageal Small Cell Carcinoma and Small Cell Lung Cancer[J]. CHINA CANCER, 2008, 17(12): 1067-1069 |
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| Authors: | WANG Yan SONG Ying XU Lin-Ping et al |
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| Affiliation: | WANG Yan1,SONG Ying2,XU Lin-Ping1,et al |
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| Abstract: | [Purpose] To investigate apoptosis biological characteristics in primary esophageal small cell carcinoma(PESC) and small cell lung cancer(SCLC). [Methods] Expression of survivin, bcl-2, caspase-3 and p53 in PESC and SCLC was detected by immunohistochemical SP method. [Results] There was no significant differene in positive expression of survivin, bcl-2, caspases-3 and p53 be- tween SCLC and PESC (P>0.05). Of negative survivin PESC and negative survivin SCLC, positive caspase-3 expression was 72.41% and 62.0... |
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| Keywords: | esophageal neoplasms small cell carcinoma small cell lung cancer cell apoptosis survivin bcl-2 caspases-3 p53 |
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