Transient growth deceleration in normal short children |
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Authors: | C Polychronakos H Abu-Srair H J Guyda |
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Institution: | (1) Department of Paediatrics, Division of Endocrinology, McGill University, 2300 Tupper Street, H3H 1P3 Montreal, Quebec, Canada;(2) Montreal Children's Hospital, 2300 Tupper Street, H3H 1P3 Montreal, Quebec, Canada |
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Abstract: | We have examined the records of 21 short children evaluated for growth hormone deficiency and found not to be deficient. Their growth velocity was evaluated for at least 6 months, both before and after testing. Without any specific therapeutic intervention, growth velocity was significantly higher after testing, as compared with before. We attribute this apparent therapeutic effect of testing to a selection bias, due to the fact that, in normal clinical practice, children are selected for testing immediately following a period of slow growth, and that decelerations of growth are very often transient. Studies of growth-stimulating treatments using children as their own controls should, for this reason, be interpreted with caution.Abbreviation GH
growth hormone
This is publication no. 87032 of the McGill University-Montreal Children's Hospital Research Institute |
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Keywords: | Growth Short stature Bias |
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