| YAP蛋白与肿瘤简 |
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| 引用本文： | 蒋宁,顾恺,牛远杰. YAP蛋白与肿瘤简[J]. 基础医学与临床, 2014, 34(2): 262-265 |
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| 作者姓名： | 蒋宁 顾恺 牛远杰 |
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| 作者单位： | 天津医科大学第二医院 |
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| 基金项目： | 雄激素非依赖性前列腺癌形成机制中肿瘤干细胞的作用;非激素依赖性前列腺癌的蛋白组学研究和分子靶向研究 |
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| 摘 要： | Hippo-YAP 信号通路是新发现的生长控制信号通路, 能够限制调结细胞的生长增殖, 细胞凋亡, 信号通路异常有利于肿瘤的发生。YAP蛋白还参与调控AKT-mTORC、WNT和MAPK等信号通路，进而影响肿瘤细胞的生长和侵润转移。YAP蛋白在多种类型的人类肿瘤中表达异常增加,或许成为肿瘤新的治疗靶点。
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| 关 键 词： | yap 蛋白 信号通路 肿瘤 |
Relationship between YAP protein and tumor |
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| Abstract: | The Hippo-yap pathway is a newly growth regulatory pathway and regulate both cell growth and apoptosis, aberrant signaling pathway contribute to tumorigenesis. YAP protein is also involved in the mediate AKT-mTORC, WNT and MAPK signaling pathways, thereby affecting tumor cell growth, invasion and metastasis. YAP protein expression is increased in many types of human tumors, perhaps to become new therapeutic targets of tumor. |
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| Keywords: | yap protein singnal pathway cancer |
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