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| 桑树细胞培养物的化学成分研究 | |
| 引用本文： | 陶小宇,张德武,陈日道,尹云泽,邹建华,谢丹,杨林,王春梅,戴均贵. 桑树细胞培养物的化学成分研究[J]. 中国中药杂志, 2012, 37(24): 3738-3742 |
| 作者姓名： | 陶小宇 张德武 陈日道 尹云泽 邹建华 谢丹 杨林 王春梅 戴均贵 |
| 作者单位： | 1. 北京中医药大学中药学院,北京100102;中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050 2. 中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京,100050 3. 中央民族大学生命与环境科学学院,北京,100081 4. 北京中医药大学中药学院,北京,100102 |
| 基金项目： | 国家自然科学基金项目(81273405);教育部博士点专项基金项目(20111106110029) |
| 摘 要： | 目的:研究桑树细胞培养物的化学成分.方法:采用多种色谱技术,对桑树悬浮细胞培养物的化学成分进行分离纯化,通过理化性质及波谱数据确定化合物结构.结果:共分离鉴定了8个化合物,分别为异补骨脂查尔酮(1),染料木素(2),norartocarpetin (3),阿尔本A(4),光桑酮E(5),桑呋喃F(6),chalcomoracin (7),桑酮J(8).结论:化合物1～8均为黄酮类化合物,其中化合物3～6为首次从桑树细胞培养物中分离得到的化合物. |
| 关 键 词： | 桑树 细胞培养物 化学成分 |
| 收稿时间： | 2012-10-29 |
Chemical constituents from cell cultures of Morus alba |
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| TAO Xiao-yu,ZHANG De-wu,CHEN Ri-dao,YIN Yun-ze,ZOU Jian-hu,XIE Dan,YANG Lin,WANG Chun-mei and DAI Jun-gui. Chemical constituents from cell cultures of Morus alba[J]. China Journal of Chinese Materia Medica, 2012, 37(24): 3738-3742 | |
| Authors: | TAO Xiao-yu ZHANG De-wu CHEN Ri-dao YIN Yun-ze ZOU Jian-hu XIE Dan YANG Lin WANG Chun-mei DAI Jun-gui |
| Affiliation: | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
| Abstract: | The column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC were used to separate and purify the compounds from the EtOAc extract of medium and MeOH extract of cell cultures of Morus alba. Eight compounds were isolated. Based on physico-chemical properties and spectroscopic data, their structures were identified as isobavachalcone (1), genistein (2), norartocarpetin (3), albanin A (4), guangsangon E (5), mulberrofuran F (6), chalcomoracin (7), kuwanon J (8). Compounds 3-6 were isolated from the cell cultures of M. alba for the first time. |
| Keywords: | Morus alba cell cultures chemical constituentes |
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