Ets-1在淋巴瘤病理组织中的表达及其意义 |
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引用本文: | 张凤,朱俊锋,倪世良,朱芳兵,周黎黎,夏瑞祥. Ets-1在淋巴瘤病理组织中的表达及其意义[J]. 实用全科医学, 2008, 6(10): 992-994,F0003 |
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作者姓名: | 张凤 朱俊锋 倪世良 朱芳兵 周黎黎 夏瑞祥 |
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作者单位: | [1]安徽省蚌埠医学院第一附属医院血液科,233004 [2]安徽医科大学第一附属医院血液科,合肥市230022 |
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摘 要: | 目的探讨淋巴瘤(lymphoma)患者病理组织中Ets-1的表达,探讨其与临床及预后的关系。方法采用免疫组织化学S-P法,检测了60例淋巴瘤、15例良性增生性淋巴结炎中Ets-1的表达。结果Ets-1蛋白在淋巴瘤和良性增生性淋巴结炎中表达于胞核,少见于胞浆。Ets-1在淋巴瘤中的阳性率为48.3%,高于良性增生性淋巴结炎的13.3%(P〈0.05)。Ⅲ、Ⅳ期淋巴瘤患者的Ets-1蛋白的表达阳性率明显高于Ⅰ、Ⅱ期患者(P〈0.05);男性组Ets-1表达阳性率为35.9%,明显低于女性组的71.4%(P〈0.001);淋巴结内组Ets-1表达阳性率为70.0%,明显高于淋巴结外病变组的26.7%(P〈0.001);Ets-1表达与年龄、组织学类型、生物学行为均无关(P〉0.05)。结论①Ets-1在淋巴瘤病理组织中表达上调,提示Ets-1可能在淋巴瘤的发生、发展中起重要作用,提示它们可能成为淋巴瘤治疗的新靶点。②Ets-1在淋巴瘤病理组织中表达上调均与Ann Arbor临床分期有关,可能是预测淋巴瘤侵袭转移和预后的相关因素。③Ets-1的表达与年龄、组织学类型、生物学行为均无关。
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关 键 词: | Ets-1 淋巴瘤 侵袭 转移 |
Expression and Significance of Ets-1 Proteins in Pathological Tissues of Lymphoma Patients |
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Affiliation: | ZHANG Feng. ZHU Jun- feng, NI Shi-liang, et al(Department of Hematology, the First Affiliated Hospital of Bengbu Medical College.Anhui 233004. China) |
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Abstract: | Objective To discuss the protein level of Ets-1 expression in the pathological tissue of lymphoma patients, and prognostic significance. Methods The expression of Ets-1 in 60 cases of lymphoma patients and 15 cases of benign hyperplastic lymphadenitis(BHL) was defected by Streptavidin-Peroxidase immunohistochemical method. Results Ets-1 protein was mainly expressed on the nucleus and seldom on cytoplasm in both lymphoma and BHL. The positive expression Tare of Ets-1 proteins in the lymphoma was 48.3% ,and higher than 13.3% of the BHL( P 〈 0.05 ). The positive expression rate of Ets-1 protein in the Ann Arbor stages of lymphoma was: Ⅲ, Ⅳstage higher than Ⅰ , Ⅱ stage( P 〈 0.05 ). The positive expression rate of Ets-1 proteins in female was 71.4% , and higher than 35.9% in male( P 〈 0. 001 ). The positive expression rate of Ets-1 proteins in intralymph node was 70.0% ,and higher than 26.7% in extra-lymph node (P 〈 0. 001 ). And the positive expression ratio of Ets-1 protein was not associated with age,lesions, histological categolT and biological behavior( P 〉 0.05 ). Conclusions The up-regulation expression of Ets-1 in lymphoma suggested that it might play synergetic roles in the progress of carcinogenesis of lymphoma, and it might identify as a potential therapeutic target in lymphoma. The expression of Ets-1 in lymphoma showed a high expression in the pathological tissues of lymphoma patients. The expression of Ets-I had a correlation with the Ann Arbor stages of lymphoma. It may be the significant factor which could predict the invasion and metastasis of lymphoma. The positive expression ratio of Ets-1 proteins was not associated with age, histological category and biological behavior. |
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Keywords: | Ets-1 |
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