盐酸普萘洛尔乳膏的安全性考察 |
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引用本文: | 苗杰,王爱武,杨柳,霍然,徐广琪.盐酸普萘洛尔乳膏的安全性考察[J].安徽医药,2014,0(6):1020-1023. |
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作者姓名: | 苗杰 王爱武 杨柳 霍然 徐广琪 |
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作者单位: | 苗杰 (山东大学附属省立医院药剂科,山东 济南 250021 山东中医药大学,山东 济南 250355); 王爱武 (山东大学附属省立医院药剂科,山东 济南,250021); 杨柳 (山东大学附属省立医院药剂科,山东 济南 250021 山东中医药大学,山东 济南 250355); 霍然 (山东大学附属省立医院烧伤整形科,山东 济南,250021); 徐广琪 (山东大学附属省立医院烧伤整形科,山东 济南 250021 山东大学医学院,山东 济南 250100); |
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基金项目: | 山东省科技发展项目(项目编号:2012YD18056) |
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摘 要: | 目的考察盐酸普萘洛尔乳膏对动物皮肤的毒性作用。方法采用不同浓度(2%、5%、10%)的盐酸普萘洛尔乳膏对家兔进行皮肤刺激性试验、对豚鼠进行过敏性试验、对Wistar大鼠进行急性毒性试验及长期毒性试验。结果 2%、5%盐酸普萘洛尔乳膏对完整、破损皮肤均无刺激性、急性毒性,对完整皮肤无明显毒性,不产生致敏作用,10%有轻微刺激性,可自行缓解。结论 2%~5%盐酸普萘洛尔乳膏是较安全的外用制剂。
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关 键 词: | 盐酸普萘洛尔乳膏 皮肤刺激性 过敏性 急性毒性 长期毒性 |
Safety evaluation of propranolol hydrochloride cream |
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Institution: | ( 1. Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China ; 2. Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China) |
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Abstract: | Objective To study the toxic action of propranolol hydrochloride cream on animal skin.Methods Dermal irritation test, dermato-allergic test,acute toxicity test and long-term toxicity test were conducted in rabbits,guinea pigs,Wistar rats respectively with different concentrations,including 2%,5%and 1 0%of propranolol hydrochloride cream.Results 2%and 5%propranolol hydrochloride cream had no acute toxicity or irritation to the intact or damaged skin and had no sensitization or overt toxicity to the intact skin. 1 0% propranolol hydrochloride cream had slight irritation,which could relieve spontaneously.Conclusion 2% and 5% propranolol hydrochloride creams are relatively safe external preparation. |
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Keywords: | propranolol hydrochloride cream dermal irritation hypersensitivity acute toxicity long-term toxicity |
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