心衰患者介入治疗后NT-proBNP水平的意义及对心肌功能预测的价值

目的 探讨心力衰竭患者介入治疗后氨基末端脑利钠肽前体（NT-proBNP）水平变化的意义以及对心功能的预测价值.方法 选取该院2011年8月至2012年8月收治的经冠脉介入治疗的100例心力衰竭的患者为研究对象,根据该组患者预后的不同分为无心血管事件组和心血管事件组,测定两组患者的NT-proBNP、C反应蛋白（CRP）、左室射血分数（LVEF）,并计算Gensini积分、Syntax积分,采用Logistic回归分析BNP水平的影响因素.结果 心血管事件组的NT-proBNP、CRP、Gensini积分、Syntax积分显著高于无心血管事件组（P＜0.05）,LVEF显著低于无心血管事件组（P＜0.05）.Logistic回归分析发现,CRP、Gensini积分、Syntax积分与BNP呈相关,LVEF与BNP呈负相关（P＜0.05）.结论 NT-proBNP在一定程度上可反映心力衰竭患者的预后,可作为心功能的预测因子.

Significance of NT-proBNP level in patients with heart failure after interventional treatment and value prediction on myocardial function

Abstract：Objective To investigate N-terminal pro brain natriuretic peptide （NT-proBNP） level changes in heart failure patients after interventional therapy and value prediction on cardiac function. Methods A hundred cases of heart failure patients in our hospital from August 2011 to August 2012 treated by percutaneous coronary intervention treatment were chosen as the research object,who were divided into cardiovascular events group and non-cardiovascular event group according to different prognosis. NT-proBNP, C reactive protein （CRP） ,left ventricular ejection fraction （LVEF）, Gensini and Syntax integral calculation were measured in two groups, and Logistic regression analysis was used to analyze the factors influencing BNP level. Results NT-proBNP, CRP, Gensini score and Syntax scores in cardiovascular events group were significantly higher than those in non-cardiovascular event groups（ P 〈 0.05 ）. LVEF was significantly lower than that in non-cardiovascular events group （ P 〈 0.05 ）. Logistic regression analysis showed that CRP, Gensini scores and Syntax scores were correlated with BNP, and LVEF negatively correlated with BNP （ P 〈 0.05 ）. Conclusion NT-proBNP can reflect the prognosis of patients with heart failure to a certain extent;it can be used as one of the predictors of cardiac function.