| NAD+代谢在细胞功能及相关疾病中作用的研究进展 |
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| 引用本文： | 何盛梅,赵厚育. NAD+代谢在细胞功能及相关疾病中作用的研究进展[J]. 基础医学与临床, 2022, 0(2) |
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| 作者姓名： | 何盛梅 赵厚育 |
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| 作者单位： | 贵州医科大学;贵州医科大学附属医院耳鼻咽喉头颈外科 |
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| 基金项目： | 国家自然科学基金(81860387);贵州省科技计划项目(黔科合基础[2020]1Y311);贵州医科大学附属医院2020年国家自然科学基金培育项目(I-2020-10)。 |
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| 摘 要： | 烟酰胺腺嘌呤二核苷酸(NAD+)是细胞内一种重要的辅助调节因子,NAD+代谢紊乱与细胞功能损伤、生理改变及疾病的发生发展密切相关。在衰老、听力障碍、心脏损伤等代谢性和年龄相关性疾病的发生过程中都伴随着NAD+水平下降,因此,通过补充恢复NAD+水平可为这些疾病的治疗提供了一种新思路。
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| 关 键 词： | 烟酰胺腺嘌呤二核苷酸 代谢 衰老 听力障碍 心脏损伤 |
Research progress on the role of NAD+metabolism in cell function and related-diseases |
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| HE Sheng-mei,ZHAO Hou-yu. Research progress on the role of NAD+metabolism in cell function and related-diseases[J]. Basic Medical Sciences and Clinics, 2022, 0(2) |
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| Authors: | HE Sheng-mei ZHAO Hou-yu |
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| Affiliation: | (Guizhou Medical University, Guiyang 550004;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China) |
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| Abstract: | Nicotinamide adenine dinucleotide(NAD+)is an important coregulatory factor in cells.The metabolic disorder of NAD+is closely related to the damage of cell function,physiological changes and the occurrence and development of diseases.The decrease of NAD+level is accompanied by the occurrence of metabolic and age-related diseases such as aging,hearing impairment and cardiac damage.Therefore,it provides a new idea for the treatment of these diseases by supplementing and restoring the level of NAD+. |
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| Keywords: | nicotinamide adenine dinucleotide metabolism aging hearing impairment cardiac damage |
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