| 黄芩素固体脂质纳米粒包封率测定及体外释放度考察 |
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| 引用本文： | 刘玉梅,朱昆,马海明.黄芩素固体脂质纳米粒包封率测定及体外释放度考察[J].实用药物与临床,2009,12(2). |
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| 作者姓名： | 刘玉梅 朱昆 马海明 |
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| 作者单位： | 吉林大学中日联谊医院,长春,130021 |
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| 摘 要： | 目的测定黄芩素固体脂质纳米粒的包封率,并考察其体外释放规律。方法溶剂扩散法制备脂质纳米粒,高速离心法分离纳米粒和游离药物,HPLC法测定包封率并考察其体外释放规律。结果测得纳米粒的平均包封率为60.73%,其体外释放规律符合H iguch i动力学方程。结论黄芩素固体脂质纳米粒有较高的包封率,在体外具有良好的缓释作用。
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| 关 键 词： | 黄芩素 固体脂质纳米粒 体外释放 |
Determination of encapsulation efficiency and release of baicalein solid lipid nanoparticles in vitro |
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| LIU Yu-mei,ZHU Kun,MA Hai-ming.Determination of encapsulation efficiency and release of baicalein solid lipid nanoparticles in vitro[J].Practical Pharmacy and Clinical Remedies,2009,12(2). |
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| Authors: | LIU Yu-mei ZHU Kun MA Hai-ming |
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| Institution: | China-Japan Union Hospital of Jilin University;Changchun 130021;China |
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| Abstract: | Objective To determine the encapsulation efficiency of baicalein solid lipid nanoparticles,and study baicalein release characteristics from the solid lipid nanoparticles in vitro.MethodsBaicalein solid lipid nanoparticles were prepared by the solvent injection method.The unencapsulated baicalein and solid lipid nanoparticles were separated by ultracentrifugation,the encapsulation efficiency was detected by HPLC.ResultsThe encapsulation efficiency of solid lipid nanoparticles was 60.73%,and the release in vi... |
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| Keywords: | Baicalein Solid lipid nanoparticle Release in vitro |
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