| 槟榔碱类似物的合成及活性初筛 |
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| 引用本文： | 邹永,钟裕国.槟榔碱类似物的合成及活性初筛[J].中国药物化学杂志,1994,4(4):252-256. |
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| 作者姓名： | 邹永 钟裕国 |
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| 作者单位： | 华西医科大学药学院药物化学教研室 |
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| 摘 要： | 以槟榔碱及其丙炔酯为先导化合物，成功地合成了Ｍ胆碱受体配基１１个化合物供筛选。初步药理实验表明部分化合物有较强的Ｍ受体拮抗作用，并对不同器官的Ｍ受体的作用表现出差异性，值得进一步研究，其中七个化合物尚未见文献报道，有三个化合物为首次分离得到。
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| 关 键 词： | M胆碱 受体 槟榔碱 槟榔啶丙炔酯 抗胆碱药 药理 |
SYNTHESIS OF ARECOLINE DERIVATIVES AND THEIR PRELIMINARY PHARMACOLOGY TESTS |
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| Zou Yong,zhong Yuguo,Jin Churong,Zhang Zuqian,Kuang Anren.SYNTHESIS OF ARECOLINE DERIVATIVES AND THEIR PRELIMINARY PHARMACOLOGY TESTS[J].Chinese Journal of Medicinal Chemistry,1994,4(4):252-256. |
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| Authors: | Zou Yong zhong Yuguo Jin Churong Zhang Zuqian Kuang Anren |
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| Abstract: | In this paper,11 derivatives have been synthesized with arecoline and arecaidine propargl ester(APE)used as lead compounds,Preliminary pharmacology tests which were compared with those of atropine and acetylcholine showed that some of them had different effects on M receptors in different organs. |
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| Keywords: | M receptors Arecoline APE Anticholinergic activity |
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