88例SARS患者心肌酶谱改变观察

目的 :了解SARS患者病程严重程度与心肌酶谱的变化及其临床意义。方法 :采用IFCC推荐方法检测心肌酶。结果 :发病初期与正常组相比 ,各病情组SARS患者血清各心肌酶活力均显著增高 (P <0 .0 1) ;SARS死亡组患者血清各心肌酶活力均显著高于其余病情组 (P <0 .0 1) ;93.1%的SARS死亡组患者发病初期血清心肌酶活力异常升高 ,而生存组这一比率 33%。发病中期 ,SARS患者血清心肌酶活力均有所降低 ,但死亡组和重症组患者血清HBDH活力未见下降。结论 :心肌是SARS病毒侵袭和损伤的重要组织之一 ,SARS患者心肌酶异常升高与病情密切相关

An observation on the variation of myocardial enzyme spectrum in serum of 88 patients with SARS

Objective:To find out the relation between the severity of SARS symptoms and the variation of myocardial enzyme spectrum and it's clinical significance. Methods:myocardial enzyme spectrum were measured by the method IFCC recommended. Results:In the initial course of SARS, The activity of each myocardial enzyme in each SARS were significantly higher than those of the normal group (P<0.01); The activity of each myocardial enzyme in serum of death group were significantly higher than other groups (P<0.01); The activity of myocardial enzyme in 93.6% of serum samples from death group rose abnormally, and the rate of survival group is 33%. In the middle stage of SARS, the activity of myocardial enzyme in serum of SARS patients decreased, but the activity of HBDH in serum from death groups and intensive symptoms groups didn't decrease. Conclusion:Myocardium is one of the important tissue invaded and damaged by SARS virus. The abnormal rise of myocardial enzyme in SARS patients relate closely to the patient's condition and prognosis.