| 普伐他汀对高脂血症老龄鼠脑缺血后行为学障碍的影响 |
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| 引用本文： | 吴剑芸,张韶冈,徐俊,杜南进,刘丰,黄文革. 普伐他汀对高脂血症老龄鼠脑缺血后行为学障碍的影响[J]. 中西医结合心脑血管病杂志, 2006, 4(7): 595-597 |
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| 作者姓名： | 吴剑芸 张韶冈 徐俊 杜南进 刘丰 黄文革 |
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| 作者单位： | 1. 广东省广州市第一人民医院,510180
2. 中山大学实验动物中心 |
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| 基金项目： | 广东省中医药管理局资助项目 |
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| 摘 要： | 目的探讨普伐他汀对高脂血症老龄鼠脑缺血后行为学障碍的影响。方法用水迷宫法分别测试脑供血不足、高脂血症及予普伐他汀干预的老龄鼠的学习记忆功能。结果高脂血症老龄鼠脑缺血后在水迷宫找到平台的时间明显延长，经过的路程明显增加；并且较非高脂脑缺血组明显，给予普伐他汀30d后改善明显，此时血脂未见明显变化。结论轻甲基戊二酸单酚CoA（HMG-CoA）还原酶抑制剂能够改善血管性痴呆的发生，其作用并不依赖于血脂降低水平，而是依赖于他汀类的调脂外作用。
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| 关 键 词： | 普伐他汀 高脂血症 血管性痴呆 |
| 文章编号： | 1672-1349(2006)07-0595-03 |
| 修稿时间： | 2006-04-17 |
The Influence of Provastatin on Behavior of Elder Encephalomalacia Mice with Hyperlipemia |
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| Wu Jianyun,Zhang Shaogang,Xu Jun,et al//. The Influence of Provastatin on Behavior of Elder Encephalomalacia Mice with Hyperlipemia[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2006, 4(7): 595-597 |
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| Authors: | Wu Jianyun Zhang Shaogang Xu Jun et al// |
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| Affiliation: | Guangzhou 510180 |
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| Abstract: | Objective To investigate the influence of provastatin on behavior of old encephalomalacia mice with hyperlipemia and the effect for vascular demen tia.Methods Learning and memory ability in elder mice with encephalomalacia and hyperlipemia,provastatin treatment was tested by water maze.Results Following treatment of provastatin, the learning and memory ability of the elder mice with encephalomalacia and hyperlipemia were improved but level of lipid was not change.Conclusion Provastatin might be a effective drugs for prevention and treatment of vascular dementia. |
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| Keywords: | provastatin hyperlipemia vascular dementia |
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