急性脑梗死患者颈动脉粥样硬化斑块与相关危险因素关系的研究

目的:探讨急性脑梗死患者颈动脉粥样硬化斑块与相关危险因素之间的关系,为脑梗死的病因诊断、治疗和预防提供重要依据。方法:84例急性脑梗死患者根据颈动脉超声检查结果,分为颈动脉粥样硬化斑块组(简称斑块组)和颈动脉粥样硬化非斑块组(简称非斑块组),并根据斑块积分将斑块组颈动脉粥样硬化程度分为3级(轻、中、重度颈动脉粥样硬化斑块),分析颈动脉粥样硬化程度与相关危险因素的关系。结果:急性脑梗死颈动脉粥样硬化斑块组与非斑块组患者的血浆CHOL、LDL-C和ApoA比较无显著差异(P>0.05),而年龄、高血压、糖尿病、CRP、白细胞计数、TG、HDL-C、ApoB、Glu和Fib在脑梗死颈动脉粥样硬化斑块组与非斑块组患者间存在显著差异(P<0.01)。结论:年龄、高血压、糖尿病、CRP、WBC计数、TG、ApoB、Glu和Fib为急性脑梗死患者颈动脉粥样硬化斑块危险因素,HDL-C为脑梗死患者颈动脉粥样硬化斑块的保护因素。

The research on relationship between the carotid plaque in acute cerebral infarction patients and relative risk facters

Objective:To discuss the relationship between the carotid plaque in acute cerebral infarction patients and the relative risk facters provide an important evidence for the pathogeny diagnosis, treatment and prevention in atherosclerotic cerebral infarction. Methods:84 acute cerebral infarction patients were diveded into carotid artary plaque group(plaque group) and non-plaque group by usingultrasound.The degree of artherosclerosis in carotid artery was classitied as slight, middle and severe , to analyze the relationship between the artherosclerosis in carotid artary and the relative risk facters. Results:The level of CHOL,LDL-C and ApoA in the two groups had not significant difference (P>0.05), but Age、hypertension、 diabetes、CRP、the cound of WBC,TG,HDL-C,ApoB,Glu and Fib in the two groups showed significant difference(P<0.01).Conclusions:Age,hypertension,diabetes,CRP,the count of WBC,TG,Glu and Fib are risk factors for artherosclerosis in carotid artary plaque in cerebral infarction patients,HDL-C is aprotective factor against carotid artary plaque.