| Job Stress, Gene Polymorphism of β2-AR, and Prevalence of Hypertension |
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| 作者姓名： | Yu SF Zhou WH Jiang KY Gu GZ Wang S |
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| 基金项目： | This research was supported by the Funds of Health Science ＆ Technology Innovation Project of Henan Province. ACKNOWLEDGEMENTS The authors would like to thank Dr. Johannes SIEGRIST for providing questionnaires. Acknowledgements also go to Peking University Health Science Center and the Funds of Health Science ＆ Technology Innovation Project of Henan Province for their financial and intellectual support for this project. |
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| 摘 要： | Objective To study the interactive effect of job stress and genetic susceptibility （or gene polymorphism） on hypertension. Methods A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. β2-AR genotypes and allele frequencies at amino acid positions 16 （β2-AR-16： Arg→Gly） and 27 （β2-AR-27： Gln→Glu） were identified by PCR-RFLE Results Job stress was related with the prevalence of hypertension in males （P〈0.05）, whereas no significant relationship was found in females （P〉0.05）. Differences in genotypes and allele frequencies of the β2-AR-16 were statistically significant between the hypertension and control groups （P〈0.05）, whereas those of β2-AR-27 were not （P〉0.05）. The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group （P〈0.01 or 0.05）. Conclusion High job stress and polymorphism of β2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.
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| 关 键 词： | 基因 多形态 高血压 临床分析 |
Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension |
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| Yu SF,Zhou WH,Jiang KY,Gu GZ,Wang S.Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension[J].Biomedical and Environmental Sciences,2008,21(3):239-246. |
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| Authors: | Yu Shan-Fa Zhou Wen-Hui Jiang Kai-You Gu Gui-Zheng Wang Sheng |
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| Institution: | [1]Department of Occupational and Environment Health, School of Public Health, Peking University, Beijing 100083, China [2]Henan Provincial Institute of Occupational Medicine, Zhengzhou 450052, Henan, China |
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| Abstract: | OBJECTIVE: To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. METHODS: A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP. RESULTS: Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05). CONCLUSION: High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers. |
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| Keywords: | Job stress Hypertension β2-AR Gene polymorphism |
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