| 维思通与氯氮平治疗精神分裂症对照分析 |
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| 引用本文： | 张聪沛 张延承. 维思通与氯氮平治疗精神分裂症对照分析[J]. 临床精神医学杂志, 1997, 7(2): 74-75 |
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| 作者姓名： | 张聪沛 张延承 |
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| 作者单位： | 哈尔滨神经精神病医院，黑龙江省司法厅医院，哈尔滨市心理卫生中心 |
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| 摘 要： | 用维思通治疗精神分裂症３３例，与用氯氮平治疗的３１例进行对照研究。两组以阴性症状量表（ＳＡＮＳ），阳性症状量表（ＳＡＰＳ），简明精神病量表（ＢＰＲＳ）和副反应量表进行盲式评分。结果显示：虽然氯氮平对治疗阴性阳性症状均有较好疗效，但维思通更明显优于氯氮平，且副作用较小。本文对维思通的疗效，临床应用，副作用，作用机理进行了讨论。
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| 关 键 词： | 维思通 氯氮平 精神分裂症 |
A controlled study comparing risperidone and clozapine in the treatment of schizophrenia |
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| Zhang Congpei,et al.. A controlled study comparing risperidone and clozapine in the treatment of schizophrenia[J]. Journal of Clinical Psychological Medicine, 1997, 7(2): 74-75 |
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| Authors: | Zhang Congpei et al. |
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| Affiliation: | Zhang Congpei,et al.Neuropsychiatric Hospital of Harbin,Heilongjiang 650056 |
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| Abstract: | Objective:To compare the therapeutic and side effects of risperidone and clozapine in the treatment of schizophrenia.Method:Thirty-three schizophrenic patients were treated with risperidone and a controlled group treated with clozapine.Both were assessed with the SAPS,SANS and BPRS,double blind,before and after treatment to evaluate the effects on positive and negative symptoms.Results:Both drugs were effective in schizophrenia with risperidone significantly superior than clozapine in treating both positive and negative symptoms.Discussion:Apart from being more effective than clozapine in treating schizophrenia,risperidone has also fewer side effects.While clozapine is also effective,it could induce potential lethal side effects such as agranulocytosis. |
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| Keywords: | Risperidone Clozapine Schizophrenia |
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