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| 左旋四氢帕马丁对条件线索诱导的大鼠海洛因复吸行为的影响 | |
| 引用本文： | 乐凯,马宝苗,田香,干永平,王代松,金国章,李超英. 左旋四氢帕马丁对条件线索诱导的大鼠海洛因复吸行为的影响[J]. 华中科技大学学报(医学版), 2011, 40(4): 455-456,476. DOI: 10.3870/j.issn.1672-0741.2011.04.018 |
| 作者姓名： | 乐凯 马宝苗 田香 干永平 王代松 金国章 李超英 |
| 作者单位： | 1. 江汉大学武汉生物医学研究院,武汉,430056 2. 湖北省公安厅禁毒总队,武汉,430070 3. 江汉大学武汉生物医学研究院,武汉,430056;中国科学院上海药物研究所,上海,201203 |
| 摘 要： | 目的研究左旋四氢帕马丁(levo-tetrahydropalmatine,l-THP)对条件线索诱导的大鼠海洛因复吸行为的干预作用。方法应用固定比率程序(fixed ratio,FR)1建立大鼠海洛因自身给药模型,戒断14 d后,观察-lTHP对条件线索诱导的大鼠海洛因复吸行为的影响。结果 2 h内l-THP组大鼠有效鼻触次数显著低于溶媒对照组(P<0.05)。结论 l-THP能有效干预条件线索诱导的大鼠海洛因复吸行为,具有预防海洛因复吸的应用前景。 |
| 关 键 词： | 左旋四氢帕马丁 海洛因复吸 条件线索 自身给药 |
Levo-tetrahydropalmatine Prevents Heroin-seeking Behavior Induced by Conditioned Cues in Rats |
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| Yue Kai#,Ma Baomiao#,Tian Xiang et alWuhan Institutes of Biomedical Sciences,Jianghan University,Wuhan ,China. Levo-tetrahydropalmatine Prevents Heroin-seeking Behavior Induced by Conditioned Cues in Rats[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2011, 40(4): 455-456,476. DOI: 10.3870/j.issn.1672-0741.2011.04.018 | |
| Authors: | Yue Kai# Ma Baomiao# Tian Xiang et alWuhan Institutes of Biomedical Sciences Jianghan University Wuhan China |
| Affiliation: | Yue Kai#,Ma Baomiao#,Tian Xiang et alWuhan Institutes of Biomedical Sciences,Jianghan University,Wuhan 430056,China |
| Abstract: | Objective To investigate the effects of levo-tetrahydropalmatine(l-THP)on conditioned cues-induced reinstatement of heroin-seeking behavior in rats.Methods Rats were trained to self-administer heroin under fixed ratio 1 schedule.Following withdrawal(14 d),rats received vehicle or l-THP treatment(ip.),and conditioned cues-induced heroin seeking behavior was recorded.Results As compared with vehicle,l-THP significantly decreased the number of active nose poke(P<0.05).Conclusion l-THP may reduce the propensity... |
| Keywords: | levo-tetrahydropalmatine heroin relapse conditioned cues self-administration |
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