艾司西酞普兰与文拉法辛治疗卒中后抑郁的临床观察

目的探讨艾司西酞普兰与文拉法辛对卒中后抑郁的疗效及安全性。方法将52例卒中后抑郁患者随机分为艾司西酞普兰与文拉法辛组各26例,观察治疗6周,于治疗前及治疗1周、2周、4周、6周末采用汉密尔顿抑郁量表和副反应量表评定抗抑郁疗效和不良反应。结果治疗6周末艾司西酞普兰与文拉法辛对卒中后抑郁有效率为76.92%、73.08%,两组比较无显著差异性（P〉0.05）,两组不良反应均轻微。结论艾司西酞普兰治疗卒中后抑郁与文拉法辛相当,且起效迅速,安全性高,依存性好,有利于患者神经功能的恢复。

Clinical Study for the Effectiveness of Escitalopram and Venlafaxine on Post-Stroke Depression Treatment

Objective This study aims at investigate the effectiveness and safety for usage of escitalopram and venlafaxine on Post-Stroke Depression.Methods 52 cases of Post-Stroke-Depression Patients participated in this study.They were randomly divided into two groups,with 26 patients in each group(A and B).Group A used escitalopram while Group B used venlafaxine,and the clinical treatment period for both groups was sis weeks.Hamilton Depression Scale and Side Reaction Measuring Scale were applied in measuring the effectiveness and side effects of these cases in the first,second,fourth and sixth week.Results The result shows that at the end of the sixth week,the effectiveness rate for the use of escitalopram is 76.92%,while the effectiveness rate for the use of venlafaxine is 73.08%;there is no significant difference between the two groups(P >0.05);there are rather slight side effects in both groups.Conclusion The functions are almost the same for the usage of escitalopram and venlafaxine on Post-Stroke Depression;both of thetwo drugs are safe,quick responding and they perform well for the function recovery of the patients.