新型隐球菌脑膜炎24例临床分析

目的 总结新型隐球菌脑膜炎的临床特点.方法 回顾性分析24例新型隐球菌脑膜炎患者的流行病学、临床表现、实验室检查及影像学资料.结果 24例患者中,男18例,女6例;12例为单纯脑膜炎,12例为脑膜脑炎.头痛23例,发热22例;脑膜刺激征阳性15例,肌力下降7例,听力下降2例.颅内压升高19例.14例治愈或明显好转,7例无明显改善,3例死亡.结论 新型隐球菌脑膜炎临床表现多种多样,容易误诊.早期诊断和及时治疗是改善预后的关键.

Cryptococcus neoformans meningitis: a clinical analysis of 24 cases

Objective To investigate the clinical features of Cryptococcus neoformans meningitis.Methods The epidemiological data,clinical manifestations,laboratory examinations,and imaging characteristics of 24 cases with Cryptococcus neoformans meningitis were retrospectively summarized.Results There were 18 male and 6 female patients with cryptococcus neoformans meningitis,12 were meningitis,12 were meningoencephalitis.Twenty-three cases were with headache,22 cases with fever,19 cases with intracranial hypertension,15 cases with positive meningeal irritation sign,7 cases with muscle weakness and 2 cases with auditory nerve damage.Fourteen cases got better after treatment,7 cases had no obvious improvement,3 cases died.Conclusion The clinical presentation of cryptococcus neoformans meningitis varies greatly,which is easy to cause misdiagnosis.Early diagnosis and timely treatment are very important to prove the prognosis.