| IUGR的胎盘病理改变及胎盘EGFR免疫组化分析 |
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| 引用本文： | 刘锡梅,尉红. IUGR的胎盘病理改变及胎盘EGFR免疫组化分析[J]. 中国优生与遗传杂志, 2005, 13(10): 37-38 |
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| 作者姓名： | 刘锡梅 尉红 |
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| 作者单位： | 山东大学齐鲁医院妇产科,250012 |
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| 摘 要： | 目的观察IUGR的胎盘病理改变及EGFR表达情况,探讨IUGR的发病机制.方法选取IUGR患者及正常妊娠妇女胎盘各18、25例,常规HE染色及EGFR免疫组化分析,观察胎盘形态学及EGFR表达情况.结果IUGR组绒毛间质纤维化及纤维素样坏死＞3%,合体滋养细胞结节＞30%,绒毛血管减少、闭塞的数量均明显高于对照组.IUGR者EGFR的表达比对照组高.结论IUGR的胎盘病理改变是造成IUGR胎盘功能减退的形态学基础.EGFR在胎儿胎盘的生长发育过程中及IUGR的病理过程中起重要作用.
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| 关 键 词： | 胎儿宫内发育迟缓 胎盘 病理学 |
| 文章编号： | 1006-9534（2005）10-0037-02 |
| 收稿时间： | 2005-03-24 |
| 修稿时间： | 2005-03-24 |
Immunohischemical analysis on the pathological change of placenta in IUGR and the expression of EGFR |
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| LIU Xi-mei,YU Hong. Immunohischemical analysis on the pathological change of placenta in IUGR and the expression of EGFR[J]. Chinese Journal of Birth Health & Heredity, 2005, 13(10): 37-38 |
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| Authors: | LIU Xi-mei YU Hong |
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| Affiliation: | Dept.of Obstet and Gynecol, Qilu Hospital of Shandong Univercity,250012 |
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| Abstract: | Objective:To observe the pathological change of placenta in IUGR and the expression of EGFR,explore the pathogenesis of IUGR.Methods:Placental samples were collected from 18 pregnancies of IUGR and from 25 normal pregnant woman.The tissue sections were assessed for morphological change with HE-stain section and analyzed by EGFR immunohistochemical technique.Results:The numbers of stroma fibrosis and fibrinoid necrosis of villi >3%,villous syncytial knots>30%,decreased and obstruction villous vascular were significantly higher in the group of IUGR than that of control group EGFR was higher in IUGR than in control group.Conclusion:The pathological changes of IUGR ard the morphological base that lead to the hypofunction of placenta EGFR has important effect on the infant growth and development and IUGR pathology process. |
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| Keywords: | EGFR |
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