| Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane/prostacyclin in Healthy Men |
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| 作者姓名： | RAYMUNDO HABITO GEORGE ANGELOS ANDREW J. SINCLAIR MADELEINE J.BALL |
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| 作者单位： | Department of Biomedical Science，University of Tasmania，TAS，Australia，Institute of Human Nutrition nnd Food，University of the Philippines Los Baos，Philippines，Department of Biomedical Science，University of Tasmania，TAS，Australia，Department of Food science，RMIT University，Melbourne，VIC，Australia，Institute of Human Nutrition and Food，University of the Philippines Los Baos，Philippines |
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| 基金项目： | This project was supported by Department of Veterans Affairs, Australia |
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| 摘 要： | Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane B_2 (TXB_2) and 6-keto prostaglandin F 1α (PGF 1α) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a 'wash-out period', before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20: 4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB_2 to 6-keto PGF 1α(P<0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB_2. Conclusions Diet rich in SFA from animal sources may influence TXA_2 formation via effect on tissu
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Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane/prostacyclin in Healthy Men |
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| RAYMUNDO HABITO,GEORGE ANGELOS,ANDREW J. SINCLAIR,MADELEINE J.BALL.Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane/prostacyclin in Healthy Men[J].Biomedical and Environmental Sciences,2003,16(4). |
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| Authors: | DUO LI RAYMUNDO HABITO GEORGE ANGELOS ANDREW JSINCLAIR MADELEINE JBALL |
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| Abstract: | Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane B2 (TXB2) and 6-keto prostaglandin F 1α (PGF 1α) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a ‘wash-out period',before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF 1α (P＜0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. Conclusions Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6. |
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| Keywords: | Thromboxane A2 Prostacyclin I2 Crossover Saturated fat Fatty acids |
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