| Lead Induced Oxidative Stress： Beneficial Effects of Kombucha Tea |
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| 作者姓名： | Dipti P Yogesh B Kain AK Pauline T Anju B Sairam M Singh B Mongia SS Kumar GI Selvamurthy W |
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| 作者单位： | DefenceInstituteofPhysiologyandAlliedSciences,LucknowRoad,Timarpur,Delhi-110054.India |
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| 摘 要： | Objective To evaluate the effect of oral administration of Kombucha tea (K-tea) on lead induced oxidative stress. Methods Sprague Dawley rats were administered 1mL of 3.8% lead acetate solution daily alone or in combination with K-tea orally for 45d, and the antioxidant status and lipid peroxidation were evaluated. Results Oral administration of lead acetate to rats enhanced lipid peroxidation and release of creatine phosphokinase and decreased levels of reduced glutathione (GSH) and andoxidant enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPx). Lead treatment did not alter humoral immunity, but inhibited DTH response when compared to the control.Lead administration also increased DNA fragmentation in liver. Oral administration of Kombucha tea to rats exposed to lead decreased lipid peroxidation and DNA damage with a concomitant increase in the reduced glutathione level and GPx activity. Kombucha tea supplementation relieved the lead induced immunosuppression to appreciable levels. Conclusion The results suggest that K-tea has potent antioxidant and immunomodulating properties.
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| 关 键 词： | 铅 氧化损伤 Kombucha茶 抗氧化作用 动物实验 GSH |
Lead induced oxidative stress: beneficial effects of Kombucha tea |
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| Dipti P,Yogesh B,Kain AK,Pauline T,Anju B,Sairam M,Singh B,Mongia SS,Kumar GI,Selvamurthy W.Lead induced oxidative stress: beneficial effects of Kombucha tea[J].Biomedical and Environmental Sciences,2003,16(3):276-282. |
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| Authors: | Dipti P Yogesh B Kain A K Pauline T Anju B Sairam M Singh B Mongia S S Kumar G Ilavazhagan Devendra Selvamurthy W |
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| Institution: | Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, India. rnprasad32@hotmail.com |
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| Abstract: | Objective To evaluate the effect of oral administration of Kombucha tea (K-tea) on lead induced oxidative stress. Methods Sprague Dawley rats were administered 1 mL of 3.8% lead acetate solution daily alone or in combination with K-tea orally for 45 d, and the antioxidant status and lipid peroxidation were evaluated. Results Oral administration of lead acetate to rats enhanced lipid peroxidation and release of creatine phosphokinase and decreased levels of reduced glutathione (GSH) and antioxidant enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPx). Lead treatment did not alter humoral immunity, but inhibited DTH response when compared to the control. Lead administration also increased DNA fragmentation in liver. Oral administration of Kombucha tea to rats exposed to lead decreased lipid peroxidation and DNA damage with a concomitant increase in the reduced glutathione level and GPx activity. Kombucha tea supplementation relieved the lead induced immunosuppression to appreciable levels. Conclusion The results suggest that K-tea has potent antioxidant and immunomodulating properties. |
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| Keywords: | Lead Oxidative stress Kombucha tea Antioxidant activity |
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