| 单核细胞趋化蛋白-1和基质金属蛋白酶-2在增生性玻璃体视网膜病变增生膜中的表达 |
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| 引用本文： | 贾洪真,韩泉洪,惠延年,王琳,杜红俊,崔志利,马吉献. 单核细胞趋化蛋白-1和基质金属蛋白酶-2在增生性玻璃体视网膜病变增生膜中的表达[J]. 眼科新进展, 2003, 23(5): 310-313 |
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| 作者姓名： | 贾洪真 韩泉洪 惠延年 王琳 杜红俊 崔志利 马吉献 |
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| 作者单位： | 710032,陕西,西安,第四军医大学西京医院,全军眼科研究所 |
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| 基金项目： | 国家自然科学基金资助(编号:30200311) |
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| 摘 要： | 目的观察单核细胞趋化蛋白-1(monocyte chemotac ticprotein-1，MCP-1)和基质金属蛋白酶-2(matrix metalloproteinase-2，MMP-2)在增生性玻璃体视网膜病变(PVR)增生膜中的表达。方法 玻璃体手术取出的PVR增生膜24例，其中C级膜11例，D级膜13例，用免疫组织化学方法检测MCP-1和MMP-2的表达。结果在全部24例增生膜中，MCP-1和MMP-2均有表达，MCP-1阳性表达8例，强阳性表达16例；MMP-2阳性表达7例，强阳性表达17例。结论MCP-1和MMP-2均存在于PVR增生膜中，提示2者在PVR增生膜的形成和PVR发生发展过程中起重要作用。
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| 关 键 词： | 增生性玻璃体视网膜病变 单核细胞趋化蛋白-1 基质金属蛋白酶-2 免疫组 织化学染色 |
| 文章编号： | 1003-5141(2003)05-0310-04 |
| 修稿时间： | 2003-08-22 |
Expression of monocyte chemotactic protein-1 and matrix metalloproteinase-2 in human periretinal membranes of proliferative vitreoretinopathy |
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| Abstract: | Objective To investigate the expression of monocyte chemotactic protein 1 (MCP 1) and matrix metalloproteinase 2(MMP 2) in human periretinal membranes of proliferative vitreoretinopathy(PVR).Methods Twenty four specimens of periretinal membranes of PVR( 11 specimens of C grade and 13 of D grade)obtained during vitrectomy were studied by immunohistochemical staining to determine the expression of MCP 1 and MMP 2.Results Immunohistochemical study indicated that MCP 1 and MMP 2 had both a positive staining in all the periretinal membranes of PVR. MCP 1 had a positive staining in 8 of 24 membranes and a strong positive staining in the remaining; MMP 2 had a positive staining in 7 of 24 membranes and a strong positive staining in the rest.Conclusion MCP 1 and MMP 2 both exist in human periretinal membranes of PVR and may play an important role in the development of PVR. |
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| Keywords: | proliferative vitreoretinopathy monocyte chemotactic protein 1 matrix metal loproteinase 2 immunohistochemical staining |
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