POEMS syndrome: Clinical,pathological and immunological study of a case |
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| Authors: | Giuseppe Orefice Vincenzo Brescia Morra Giuseppe De Michele Caterina Fusco Guglielmo Borgia Raimondo Cerini |
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| Affiliation: | 1. Departments of Neurology, Naples, Italy;2. Infectious Diseases, Federico II University, Naples, Italy;3. Blood Center;4. A. Cardarelli Hospital, U.S.L 40, Naples, Italy |
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| Abstract: | AbstractA young Italian woman with a POEMS syndrome is described. The patient had a plasma cell dyscrasia without clinical or laboratory evidence of multiple myeloma. The phenotypic analysis of bone marrow cells and peripheral blood lymphocytes revealed a normal pattern. The immunological study of CSF showed high levels of interleukin-6, whereas this cytokine was not detectable in the serum. Electrophysiological studies and sural nerve biopsy showed a mixed, demyelinating-axonal sensorimotor neuropathy with marked loss of large myelinated fibres. Long-term treatment with prednisone gave some clinical improvement. [Neurol Res 1994; 16: 477-480] |
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| Keywords: | POEMS syndrome plasma cell dyscrasia interleukin-6 prednisone |
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