Effect of high simple dose of cisplatinum and of radiation on the brain of rabbit |
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Authors: | Natalio Walach Gili Lushkov Abraham Nyska Ruth Gur Lea Pollak Juana Schiffer |
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Affiliation: | 1. Department of Oncology, Hebrew University of Jerusalem, Israel;2. Surgical Research Laboratory, Hebrew University of Jerusalem, Israel;3. Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Israel;4. +Department of Neurosurgery, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel |
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Abstract: | AbstractIn former studies of intracarotid and intravenous administration of cisplatinum, separate and combined with brain irradiation, we found no cerebral damage. In this study! gradually increasing high doses (above the therapeutic ones) of cisplatinum were administered intravenously to one series of rabbits arid increasing high amounts of irradiation (above the therapeutic amounts) were given to another series. Although the rabbits that received highest doses of irradiation developed areas of alopecia and skin ulcers on the head! the general clinical and histopathologic examination of the rabbits brains in both series was normal. The purpose of this study was to establish the effects of high doses of intravenous cisplatinum and irradiation on the rabbits brains. [Neural Res 1997; 19: 216–218] |
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Keywords: | Cisplatinum Irradiation Brain tumor Rabbit |
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