Effect of VA-045, a novel apovincaminic acid derivative,on closed head injury-induced neurological dysfunction in aged rats |
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| Authors: | Shigeru Okuyama Shigeyuki Yamada Shin-ichi Ogawa Katsuji Shima Katsuo Kamata Kazuyuki Tomisawa |
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| Affiliation: | 1. Medicinal Research Laboratories, Taisho Pharmaceutical CO., Ohmiya, Saitama, Japan;2. Nihon Bioresearch Center Inc., Hashima, Gifu;3. Department of Neurosurgery, National Defense Medical College, Tokorozawa;4. Department of Physiology and Morphology, Institute of Medicinal Chemistry, Tokyo, Japan |
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| Abstract: | Abstract Objective: The strength–duration time constant (SDTC) is a measure of axonal excitability and it can provide information about Na+ channel function. In this study, we sought to examine the changes in the SDTCs of motor and sensory fibers of the median nerve in patients taking colchicine, which affects axoplasmic flow and may result in axonal neuropathy. Methods and results: The SDTCs of motor and sensory fibers of 29 patients who had been taking colchicine were measured following stimulation of the right median nerve at the wrist. The results were compared with ten healthy age-matched subjects. No significant differences were found between the groups. Conclusions: The lack of any effect on the SDTC by colchicine might have been due to the fact that axonal degeneration caused by colchicine affects the Na+–K+ ATP pump or that it affects internodal channels other than nodal channels. |
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| Keywords: | Closed head injury Motor deficits Aged rats VA-045 TRH |
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