SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population |
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| Authors: | Mahjoubeh Zarrabi Alhosseini Javad Jamshidi Alireza Zare Bidoki Saeid Ganji Mohammad Reza Eslami Amirabadi Babak Emamalizadeh |
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| Affiliation: | 1. Faculty of Basic Sciences, Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;3. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Mehr Hospital, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Psychiatry, Imam Hossein Medical Hospital, Shahid Behashti University of Medical Sciences, Tehran, Iran;6. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD.Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6–16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6–16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped.Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD.Discussion: To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD. |
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| Keywords: | ADHD SNAP-25 Variation Polymorphism Iranian |
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